Men's Rogaine Extra Strength has helped millions of men treat their hair loss. One reason men choose Rogaine is it's safe enough to use without a prescription. Rogaine is a topical liquid, not a systemic medication. That means it’s applied to the top of your scalp, instead of taken internally. You'll be relieved to know that Men's Rogaine Extra Strength works without altering male hormones. A small percentage of users, about 6%, experience scalp irritation. If that happens to you, make sure you wash your hair with a gentle shampoo — like PROGAINE®. You can also use a mild dandruff shampoo twice a week to help keep your scalp healthy. If the irritation still doesn't clear up, see your doctor.